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- Title
COL11A1 in FAP polyps and in sporadic colorectal tumors.
- Authors
Fischer, H; Salahshor, S; Stenling, R; Björk, J; Lindmark, G; Iselius, L; Rubio, C; Lindblom, A
- Abstract
We previously reported that the alpha-1 chain of type 11 collagen (COL11A1), not normally expressed in the colon, was up-regulated in stromal fibroblasts in most sporadic colorectal carcinomas. Patients with germline mutations in the APC gene show, besides colonic polyposis, symptoms of stromal fibroblast involvement, which could be related to COL11A1 expression. Most colorectal carcinomas are suggested to be a result of an activated Wnt- pathway, most often involving an inactivation of the APC gene or activation of beta-catenin.
- Publication
BMC cancer, 2001, Vol 1, p17
- ISSN
1471-2407
- Publication type
Journal Article
- DOI
10.1186/1471-2407-1-17