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- Title
Sequence divergence of Mus spretus and Mus musculus across a skin cancer susceptibility locus.
- Authors
Mahler, Kimberly L; Fleming, Jessica L; Dworkin, Amy M; Gladman, Nicholas; Cho, Hee-Yeon; Mao, Jian-Hua; Balmain, Allan; Toland, Amanda Ewart
- Abstract
Mus spretus diverged from Mus musculus over one million years ago. These mice are genetically and phenotypically divergent. Despite the value of utilizing M. musculus and M. spretus for quantitative trait locus (QTL) mapping, relatively little genomic information on M. spretus exists, and most of the available sequence and polymorphic data is for one strain of M. spretus, Spret/Ei. In previous work, we mapped fifteen loci for skin cancer susceptibility using four different M. spretus by M. musculus F1 backcrosses. One locus, skin tumor susceptibility 5 (Skts5) on chromosome 12, shows strong linkage in one cross.
- Publication
BMC genomics, 2008, Vol 9, p626
- ISSN
1471-2164
- Publication type
Journal Article
- DOI
10.1186/1471-2164-9-626