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- Title
Transcriptomic responses to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in liver: comparison of rat and mouse.
- Authors
Boutros, Paul C; Yan, Rui; Moffat, Ivy D; Pohjanvirta, Raimo; Okey, Allan B
- Abstract
Mouse and rat models are mainstays in pharmacology, toxicology and drug development -- but differences between strains and between species complicate data interpretation and application to human health. Dioxin-like polyhalogenated aromatic hydrocarbons represent a major class of environmentally and economically relevant toxicants. In mammals dioxin exposure leads to a broad spectrum of adverse affects, including hepatotoxicity of varying severity. Several studies have shown that dioxins extensively alter hepatic mRNA levels. Surprisingly, though, analysis of a limited portion of the transcriptome revealed that rat and mouse responses diverge greatly (Boverhof et al. Toxicol Sci 94:398-416, 2006).
- Publication
BMC genomics, 2008, Vol 9, p419
- ISSN
1471-2164
- Publication type
Journal Article
- DOI
10.1186/1471-2164-9-419