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- Title
Genetic interaction network of the Saccharomyces cerevisiae type 1 phosphatase Glc7.
- Authors
Logan, Michael R; Nguyen, Thao; Szapiel, Nicolas; Knockleby, James; Por, Hanting; Zadworny, Megan; Neszt, Michael; Harrison, Paul; Bussey, Howard; Mandato, Craig A; Vogel, Jackie; Lesage, Guillaume
- Abstract
Protein kinases and phosphatases regulate protein phosphorylation, a critical means of modulating protein function, stability and localization. The identification of functional networks for protein phosphatases has been slow due to their redundant nature and the lack of large-scale analyses. We hypothesized that a genome-scale analysis of genetic interactions using the Synthetic Genetic Array could reveal protein phosphatase functional networks. We apply this approach to the conserved type 1 protein phosphatase Glc7, which regulates numerous cellular processes in budding yeast.
- Publication
BMC genomics, 2008, Vol 9, p336
- ISSN
1471-2164
- Publication type
Journal Article
- DOI
10.1186/1471-2164-9-336