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- Title
The plasticizer butyl benzyl phthalate induces genomic changes in rat mammary gland after neonatal/prepubertal exposure.
- Authors
Moral, Raquel; Wang, Richard; Russo, Irma H; Mailo, Daniel A; Lamartiniere, Coral A; Russo, Jose
- Abstract
Phthalate esters like n-butyl benzyl phthalate (BBP) are widely used plasticizers. BBP has shown endocrine-disrupting properties, thus having a potential effect on hormone-sensitive tissues. The aim of this study is to determine the effect of neonatal/prepubertal exposure (post-natal days 2-20) to BBP on maturation parameters and on the morphology, proliferative index and genomic signature of the rat mammary gland at different ages of development (21, 35, 50 and 100 days).
- Publication
BMC genomics, 2007, Vol 8, p453
- ISSN
1471-2164
- Publication type
Journal Article
- DOI
10.1186/1471-2164-8-453