We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
The complement of protein kinases of the microsporidium Encephalitozoon cuniculi in relation to those of Saccharomyces cerevisiae and Schizosaccharomyces pombe.
- Authors
Miranda-Saavedra, Diego; Stark, Michael J R; Packer, Jeremy C; Vivares, Christian P; Doerig, Christian; Barton, Geoffrey J
- Abstract
Microsporidia, parasitic fungi-related eukaryotes infecting many cell types in a wide range of animals (including humans), represent a serious health threat in immunocompromised patients. The 2.9 Mb genome of the microsporidium Encephalitozoon cuniculi is the smallest known of any eukaryote. Eukaryotic protein kinases are a large superfamily of enzymes with crucial roles in most cellular processes, and therefore represent potential drug targets. We report here an exhaustive analysis of the E. cuniculi genomic database aimed at identifying and classifying all protein kinases of this organism with reference to the kinomes of two highly-divergent yeast species, Saccharomyces cerevisiae and Schizosaccharomyces pombe.
- Publication
BMC genomics, 2007, Vol 8, p309
- ISSN
1471-2164
- Publication type
Journal Article
- DOI
10.1186/1471-2164-8-309