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- Title
EGFR associated expression profiles vary with breast tumor subtype.
- Authors
Hoadley, Katherine A; Weigman, Victor J; Fan, Cheng; Sawyer, Lynda R; He, Xiaping; Troester, Melissa A; Sartor, Carolyn I; Rieger-House, Thais; Bernard, Philip S; Carey, Lisa A; Perou, Charles M
- Abstract
The epidermal growth factor receptor (EGFR/HER1) and its downstream signaling events are important for regulating cell growth and behavior in many epithelial tumors types. In breast cancer, the role of EGFR is complex and appears to vary relative to important clinical features including estrogen receptor (ER) status. To investigate EGFR-signaling using a genomics approach, several breast basal-like and luminal epithelial cell lines were examined for sensitivity to EGFR inhibitors. An EGFR-associated gene expression signature was identified in the basal-like SUM102 cell line and was used to classify a diverse set of sporadic breast tumors.
- Publication
BMC genomics, 2007, Vol 8, p258
- ISSN
1471-2164
- Publication type
Journal Article
- DOI
10.1186/1471-2164-8-258