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- Title
C-terminal motif prediction in eukaryotic proteomes using comparative genomics and statistical over-representation across protein families.
- Authors
Austin, Ryan S; Provart, Nicholas J; Cutler, Sean R
- Abstract
The carboxy termini of proteins are a frequent site of activity for a variety of biologically important functions, ranging from post-translational modification to protein targeting. Several short peptide motifs involved in protein sorting roles and dependent upon their proximity to the C-terminus for proper function have already been characterized. As a limited number of such motifs have been identified, the potential exists for genome-wide statistical analysis and comparative genomics to reveal novel peptide signatures functioning in a C-terminal dependent manner. We have applied a novel methodology to the prediction of C-terminal-anchored peptide motifs involving a simple z-statistic and several techniques for improving the signal-to-noise ratio.
- Publication
BMC genomics, 2007, Vol 8, p191
- ISSN
1471-2164
- Publication type
Journal Article
- DOI
10.1186/1471-2164-8-191