We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Operon information improves gene expression estimation for cDNA microarrays.
- Authors
Xiao, Guanghua; Martinez-Vaz, Betsy; Pan, Wei; Khodursky, Arkady B
- Abstract
In prokaryotic genomes, genes are organized in operons, and the genes within an operon tend to have similar levels of expression. Because of co-transcription of genes within an operon, borrowing information from other genes within the same operon can improve the estimation of relative transcript levels; the estimation of relative levels of transcript abundances is one of the most challenging tasks in experimental genomics due to the high noise level in microarray data. Therefore, techniques that can improve such estimations, and moreover are based on sound biological premises, are expected to benefit the field of microarray data analysis
- Publication
BMC genomics, 2006, Vol 7, p87
- ISSN
1471-2164
- Publication type
Journal Article
- DOI
10.1186/1471-2164-7-87