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Title
Gene connectivity, function, and sequence conservation: predictions from modular yeast co-expression networks.
Authors
Carlson, Marc R J; Zhang, Bin; Fang, Zixing; Mischel, Paul S; Horvath, Steve; Nelson, Stanley F
Abstract
Genes and proteins are organized into functional modular networks in which the network context of a gene or protein has implications for cellular function. Highly connected hub proteins, largely responsible for maintaining network connectivity, have been found to be much more likely to be essential for yeast survival.