We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Simultaneous host and parasite expression profiling identifies tissue-specific transcriptional programs associated with susceptibility or resistance to experimental cerebral malaria.
- Authors
Lovegrove, Fiona E; Peña-Castillo, Lourdes; Mohammad, Naveed; Liles, W Conrad; Hughes, Timothy R; Kain, Kevin C
- Abstract
The development and outcome of cerebral malaria (CM) reflects a complex interplay between parasite-expressed virulence factors and host response to infection. The murine CM model, Plasmodium berghei ANKA (PbA), which simulates many of the features of human CM, provides an excellent system to study this host/parasite interface. We designed "combination" microarrays that concurrently detect genome-wide transcripts of both PbA and mouse, and examined parasite and host transcriptional programs during infection of CM-susceptible (C57BL/6) and CM-resistant (BALB/c) mice.
- Publication
BMC genomics, 2006, Vol 7, p295
- ISSN
1471-2164
- Publication type
Journal Article
- DOI
10.1186/1471-2164-7-295