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- Title
In silico and microarray-based genomic approaches to identifying potential vaccine candidates against Leptospira interrogans.
- Authors
Yang, Hong-Liang; Zhu, Yong-Zhang; Qin, Jin-Hong; He, Ping; Jiang, Xu-Cheng; Zhao, Guo-Ping; Guo, Xiao-Kui
- Abstract
Currently available vaccines against leptospirosis are of low efficacy, have an unacceptable side-effect profile, do not induce long-term protection, and provide no cross-protection against the different serovars of pathogenic leptospira. The current major focus in leptospirosis research is to discover conserved protective antigens that may elicit longer-term protection against a broad range of Leptospira. There is a need to screen vaccine candidate genes in the genome of Leptospira interrogans.
- Publication
BMC genomics, 2006, Vol 7, p293
- ISSN
1471-2164
- Publication type
Journal Article
- DOI
10.1186/1471-2164-7-293