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- Title
In vitro identification and in silico utilization of interspecies sequence similarities using GeneChip technology.
- Authors
Grigoryev, Dmitry N; Ma, Shwu-Fan; Simon, Brett A; Irizarry, Rafael A; Ye, Shui Q; Garcia, Joe G N
- Abstract
Genomic approaches in large animal models (canine, ovine etc) are challenging due to insufficient genomic information for these species and the lack of availability of corresponding microarray platforms. To address this problem, we speculated that conserved interspecies genetic sequences can be experimentally detected by cross-species hybridization. The Affymetrix platform probe redundancy offers flexibility in selecting individual probes with high sequence similarities between related species for gene expression analysis.
- Publication
BMC genomics, 2005, Vol 6, p62
- ISSN
1471-2164
- Publication type
Journal Article
- DOI
10.1186/1471-2164-6-62