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- Title
Assessment of the genomic variation in a cattle population by re-sequencing of key animals at low to medium coverage.
- Authors
Jansen, Sandra; Aigner, Bernhard; Pausch, Hubert; Wysocki, Michal; Eck, Sebastian; Benet-Pagès, Anna; Graf, Elisabeth; Wieland, Thomas; Strom, Tim M; Meitinger, Thomas; Fries, Ruedi
- Abstract
Genome- and population-wide re-sequencing would allow for most efficient detection of causal trait variants. However, despite a strong decrease of costs for next-generation sequencing in the last few years, re-sequencing of large numbers of individuals is not yet affordable. We therefore resorted to re-sequencing of a limited number of bovine animals selected to explain a major proportion of the population's genomic variation, so called key animals, in order to provide a catalogue of functional variants and a substrate for population- and genome-wide imputation of variable sites.
- Publication
BMC genomics, 2013, Vol 14, p446
- ISSN
1471-2164
- Publication type
Journal Article
- DOI
10.1186/1471-2164-14-446