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- Title
Gene expression differences during the heterogeneous progression of peripheral atherosclerosis in familial hypercholesterolemic swine.
- Authors
Bahls, Martin; Bidwell, Christopher A; Hu, Juan; Tellez, Armando; Kaluza, Greg L; Granada, Juan F; Krueger, Christian G; Reed, Jess D; Laughlin, M Harold; Van Alstine, William G; Newcomer, Sean C
- Abstract
The heterogeneous progression of atherosclerotic disease in the peripheral arteries is currently not well understood. In humans, artery specific disease progression is partly attributed to the local hemodynamic environments. However, despite similar hemodynamic environments, porcine brachial arteries are protected while femoral arteries are highly susceptible to advanced lesion formation. The aim of this investigation was to determine whether artery specific gene expression patterns contribute to the uneven distribution of peripheral arterial disease (PAD) in Rapacz Familial-Hypercholesterolemic (FHC) swine.
- Publication
BMC genomics, 2013, Vol 14, p443
- ISSN
1471-2164
- Publication type
Journal Article
- DOI
10.1186/1471-2164-14-443