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- Title
Alternative splicing tends to avoid partial removals of protein-protein interaction sites.
- Authors
Colantoni, Alessio; Bianchi, Valerio; Gherardini, Pier Federico; Tomba, Gianpaolo Scalia; Ausiello, Gabriele; Helmer-Citterich, Manuela; Ferrè, Fabrizio
- Abstract
Anecdotal evidence of the involvement of alternative splicing (AS) in the regulation of protein-protein interactions has been reported by several studies. AS events have been shown to significantly occur in regions where a protein interaction domain or a short linear motif is present. Several AS variants show partial or complete loss of interface residues, suggesting that AS can play a major role in the interaction regulation by selectively targeting the protein binding sites. In the present study we performed a statistical analysis of the alternative splicing of a non-redundant dataset of human protein-protein interfaces known at molecular level to determine the importance of this way of modulation of protein-protein interactions through AS.
- Publication
BMC genomics, 2013, Vol 14, p379
- ISSN
1471-2164
- Publication type
Journal Article
- DOI
10.1186/1471-2164-14-379