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- Title
Changes in the transcriptome of the malaria parasite Plasmodium falciparum during the initial phase of transmission from the human to the mosquito.
- Authors
Ngwa, Che Julius; Scheuermayer, Matthias; Mair, Gunnar Rudolf; Kern, Selina; Brügl, Thomas; Wirth, Christine Clara; Aminake, Makoah Nigel; Wiesner, Jochen; Fischer, Rainer; Vilcinskas, Andreas; Pradel, Gabriele
- Abstract
The transmission of the malaria parasite Plasmodium falciparum from the human to the mosquito is mediated by dormant sexual precursor cells, the gametocytes, which become activated in the mosquito midgut. Because gametocytes are the only parasite stages able to establish an infection in the mosquito, they play a crucial role in spreading the tropical disease. The human-to-mosquito transmission triggers important molecular changes in the gametocytes, which initiate gametogenesis and prepare the parasite for life-cycle progression in the insect vector.
- Publication
BMC genomics, 2013, Vol 14, p256
- ISSN
1471-2164
- Publication type
Journal Article
- DOI
10.1186/1471-2164-14-256