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- Title
Sequencing of the core MHC region of black grouse (Tetrao tetrix) and comparative genomics of the galliform MHC.
- Authors
Wang, Biao; Ekblom, Robert; Strand, Tanja M; Portela-Bens, Silvia; Höglund, Jacob
- Abstract
The MHC, which is regarded as the most polymorphic region in the genomes of jawed vertebrates, plays a central role in the immune system by encoding various proteins involved in the immune response. The chicken MHC-B genomic region has a highly streamlined gene content compared to mammalian MHCs. Its core region includes genes encoding Class I and Class IIB molecules but is only ~92Kb in length. Sequences of other galliform MHCs show varying degrees of similarity as that of chicken. The black grouse (Tetrao tetrix) is a wild galliform bird species which is an important model in conservation genetics and ecology. We sequenced the black grouse core MHC-B region and combined this with available data from related species (chicken, turkey, gold pheasant and quail) to perform a comparative genomics study of the galliform MHC. This kind of analysis has previously been severely hampered by the lack of genomic information on avian MHC regions, and the galliformes is still the only bird lineage where such a comparison is possible.
- Publication
BMC genomics, 2012, Vol 13, p553
- ISSN
1471-2164
- Publication type
Journal Article
- DOI
10.1186/1471-2164-13-553