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- Title
In depth comparison of an individual's DNA and its lymphoblastoid cell line using whole genome sequencing.
- Authors
Nickles, Dorothee; Madireddy, Lohith; Yang, Shan; Khankhanian, Pouya; Lincoln, Steve; Hauser, Stephen L; Oksenberg, Jorge R; Baranzini, Sergio E
- Abstract
A detailed analysis of whole genomes can be now achieved with next generation sequencing. Epstein Barr Virus (EBV) transformation is a widely used strategy in clinical research to obtain an unlimited source of a subject's DNA. Although the mechanism of transformation and immortalization by EBV is relatively well known at the transcriptional and proteomic level, the genetic consequences of EBV transformation are less well understood. A detailed analysis of the genetic alterations introduced by EBV transformation is highly relevant, as it will inform on the usefulness and limitations of this approach.
- Publication
BMC genomics, 2012, Vol 13, p477
- ISSN
1471-2164
- Publication type
Journal Article
- DOI
10.1186/1471-2164-13-477