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- Title
A mechanistic basis for amplification differences between samples and between genome regions.
- Authors
Veal, Colin D; Freeman, Peter J; Jacobs, Kevin; Lancaster, Owen; Jamain, Stéphane; Leboyer, Marion; Albanes, Demetrius; Vaghela, Reshma R; Gut, Ivo; Chanock, Stephen J; Brookes, Anthony J
- Abstract
For many analytical methods the efficiency of DNA amplification varies across the genome and between samples. The most affected genome regions tend to correlate with high C + G content, however this relationship is complex and does not explain why the direction and magnitude of effects varies considerably between samples.
- Publication
BMC genomics, 2012, Vol 13, p455
- ISSN
1471-2164
- Publication type
Journal Article
- DOI
10.1186/1471-2164-13-455