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- Title
The role of Transposable Elements in shaping the combinatorial interaction of Transcription Factors.
- Authors
Testori, Alessandro; Caizzi, Livia; Cutrupi, Santina; Friard, Olivier; De Bortoli, Michele; Cora', Davide; Caselle, Michele
- Abstract
In the last few years several studies have shown that Transposable Elements (TEs) in the human genome are significantly associated with Transcription Factor Binding Sites (TFBSs) and that in several cases their expansion within the genome led to a substantial rewiring of the regulatory network. Another important feature of the regulatory network which has been thoroughly studied is the combinatorial organization of transcriptional regulation. In this paper we combine these two observations and suggest that TEs, besides rewiring the network, also played a central role in the evolution of particular patterns of combinatorial gene regulation.
- Publication
BMC genomics, 2012, Vol 13, p400
- ISSN
1471-2164
- Publication type
Journal Article
- DOI
10.1186/1471-2164-13-400