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- Title
Ultra-high resolution HLA genotyping and allele discovery by highly multiplexed cDNA amplicon pyrosequencing.
- Authors
Lank, Simon M; Golbach, Brittney A; Creager, Hannah M; Wiseman, Roger W; Keskin, Derin B; Reinherz, Ellis L; Brusic, Vladimir; O'Connor, David H
- Abstract
High-resolution HLA genotyping is a critical diagnostic and research assay. Current methods rarely achieve unambiguous high-resolution typing without making population-specific frequency inferences due to a lack of locus coverage and difficulty in exon-phase matching. Achieving high-resolution typing is also becoming more challenging with traditional methods as the database of known HLA alleles increases.
- Publication
BMC genomics, 2012, Vol 13, p378
- ISSN
1471-2164
- Publication type
Journal Article
- DOI
10.1186/1471-2164-13-378