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- Title
On the origin of Mycobacterium ulcerans, the causative agent of Buruli ulcer.
- Authors
Doig, Kenneth D; Holt, Kathryn E; Fyfe, Janet A M; Lavender, Caroline J; Eddyani, Miriam; Portaels, Françoise; Yeboah-Manu, Dorothy; Pluschke, Gerd; Seemann, Torsten; Stinear, Timothy P
- Abstract
Mycobacterium ulcerans is an unusual bacterial pathogen with elusive origins. While closely related to the aquatic dwelling M. marinum, M. ulcerans has evolved the ability to produce the immunosuppressive polyketide toxin mycolactone and cause the neglected tropical disease Buruli ulcer. Other mycolactone-producing mycobacteria (MPM) have been identified in fish and frogs and given distinct species designations (M. pseudoshottsii, M. shinshuense, M. liflandii and M. marinum), however the evolution of M. ulcerans and its relationship to other MPM has not been defined. Here we report the comparative analysis of whole genome sequences from 30 MPM and five M. marinum.
- Publication
BMC genomics, 2012, Vol 13, p258
- ISSN
1471-2164
- Publication type
Journal Article
- DOI
10.1186/1471-2164-13-258