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Title
Correlating CpG islands, motifs, and sequence variants in human chromosome 21.
Authors
Spontaneo, Leah; Cercone, Nick
Abstract
CpG islands are important regions in DNA. They usually appear at the 5' end of genes containing GC-rich dinucleotides. When DNA methylation occurs, gene regulation is affected and it sometimes leads to carcinogenesis. We propose a new detection program using a hidden-markov model alongside the Viterbi algorithm.