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- Title
The interplay between evolution, regulation and tissue specificity in the Human Hereditary Diseasome.
- Authors
Nagaraj, Shivashankar H; Ingham, Aaron; Reverter, Antonio
- Abstract
Human disease genes can be distinguished from essential (embryonically lethal) and non-disease genes using gene attributes. Such attributes include gene age, tissue specificity of expression, regulatory capacity, sequence length, rate of sequence variation and capacity for interaction. The resulting information has been used to inform data mining approaches seeking to identify novel disease genes. Given the dynamic nature of this field and the rapid rise in relevant information, we have chosen to perform a single integrated mining approach to explore relationships among gene attributes and thereby characterise evolutionary trends associated with disease genes.
- Publication
BMC genomics, 2010, Vol 11 Suppl 4, pS23
- ISSN
1471-2164
- Publication type
Journal Article
- DOI
10.1186/1471-2164-11-S4-S23