We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Transcriptional changes in response to X chromosome dosage in the mouse: implications for X inactivation and the molecular basis of Turner Syndrome.
- Authors
Lopes, Alexandra M; Burgoyne, Paul S; Ojarikre, Andrew; Bauer, Julien; Sargent, Carole A; Amorim, António; Affara, Nabeel A
- Abstract
X monosomic mice (39,XO) have a remarkably mild phenotype when compared to women with Turner syndrome (45,XO). The generally accepted hypothesis to explain this discrepancy is that the number of genes on the mouse X chromosome which escape X inactivation, and thus are expressed at higher levels in females, is very small. However this hypothesis has never been tested and only a small number of genes have been assayed for their X-inactivation status in the mouse. We performed a global expression analysis in four somatic tissues (brain, liver, kidney and muscle) of adult 40,XX and 39,XO mice using the Illumina Mouse WG-6 v1_1 Expression BeadChip and an extensive validation by quantitative real time PCR, in order to identify which genes are expressed from both X chromosomes.
- Publication
BMC genomics, 2010, Vol 11, p82
- ISSN
1471-2164
- Publication type
Journal Article
- DOI
10.1186/1471-2164-11-82