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- Title
Perturbation of the yeast N-acetyltransferase NatB induces elevation of protein phosphorylation levels.
- Authors
Helbig, Andreas O; Rosati, Sara; Pijnappel, Pim W W M; van Breukelen, Bas; Timmers, Marc H T H; Mohammed, Shabaz; Slijper, Monique; Heck, Albert J R
- Abstract
The addition of an acetyl group to protein N-termini is a widespread co-translational modification. NatB is one of the main N-acetyltransferases that targets a subset of proteins possessing an N-terminal methionine, but so far only a handful of substrates have been reported. Using a yeast nat3Δ strain, deficient for the catalytic subunit of NatB, we employed a quantitative proteomics strategy to identify NatB substrates and to characterize downstream effects in nat3Δ.
- Publication
BMC genomics, 2010, Vol 11, p685
- ISSN
1471-2164
- Publication type
Journal Article
- DOI
10.1186/1471-2164-11-685