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- Title
Genome sequence of adherent-invasive Escherichia coli and comparative genomic analysis with other E. coli pathotypes.
- Authors
Nash, John He; Villegas, Andre; Kropinski, Andrew M; Aguilar-Valenzuela, Renan; Konczy, Paulina; Mascarenhas, Mariola; Ziebell, Kim; Torres, Alfredo G; Karmali, Mohamed A; Coombes, Brian K
- Abstract
Adherent and invasive Escherichia coli (AIEC) are commonly found in ileal lesions of Crohn's Disease (CD) patients, where they adhere to intestinal epithelial cells and invade into and survive in epithelial cells and macrophages, thereby gaining access to a typically restricted host niche. Colonization leads to strong inflammatory responses in the gut suggesting that AIEC could play a role in CD immunopathology. Despite extensive investigation, the genetic determinants accounting for the AIEC phenotype remain poorly defined. To address this, we present the complete genome sequence of an AIEC, revealing the genetic blueprint for this disease-associated E. coli pathotype.
- Publication
BMC genomics, 2010, Vol 11, p667
- ISSN
1471-2164
- Publication type
Journal Article
- DOI
10.1186/1471-2164-11-667