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- Title
Expression proteomics of UPF1 knockdown in HeLa cells reveals autoregulation of hnRNP A2/B1 mediated by alternative splicing resulting in nonsense-mediated mRNA decay.
- Authors
McGlincy, Nicholas J; Tan, Lit-Yeen; Paul, Nicodeme; Zavolan, Mihaela; Lilley, Kathryn S; Smith, Christopher W J
- Abstract
In addition to acting as an RNA quality control pathway, nonsense-mediated mRNA decay (NMD) plays roles in regulating normal gene expression. In particular, the extent to which alternative splicing is coupled to NMD and the roles of NMD in regulating uORF containing transcripts have been a matter of debate.
- Publication
BMC genomics, 2010, Vol 11, p565
- ISSN
1471-2164
- Publication type
Journal Article
- DOI
10.1186/1471-2164-11-565