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- Title
Gene expression profiling in the stress control brain region hypothalamic paraventricular nucleus reveals a novel gene network including amyloid beta precursor protein.
- Authors
Tsolakidou, Amalia; Czibere, Ludwig; Pütz, Benno; Trümbach, Dietrich; Panhuysen, Markus; Deussing, Jan M; Wurst, Wolfgang; Sillaber, Inge; Landgraf, Rainer; Holsboer, Florian; Rein, Theo
- Abstract
The pivotal role of stress in the precipitation of psychiatric diseases such as depression is generally accepted. This study aims at the identification of genes that are directly or indirectly responding to stress. Inbred mouse strains that had been evidenced to differ in their stress response as well as in their response to antidepressant treatment were chosen for RNA profiling after stress exposure. Gene expression and regulation was determined by microarray analyses and further evaluated by bioinformatics tools including pathway and cluster analyses.
- Publication
BMC genomics, 2010, Vol 11, p546
- ISSN
1471-2164
- Publication type
Journal Article
- DOI
10.1186/1471-2164-11-546