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- Title
Deep sequencing of small RNA libraries reveals dynamic regulation of conserved and novel microRNAs and microRNA-stars during silkworm development.
- Authors
Jagadeeswaran, Guru; Zheng, Yun; Sumathipala, Niranji; Jiang, Haobo; Arrese, Estela L; Soulages, Jose L; Zhang, Weixiong; Sunkar, Ramanjulu
- Abstract
In eukaryotes, microRNAs (miRNAs) have emerged as critical regulators of gene expression. The Silkworm (Bombyx mori L.) is one of the most suitable lepidopteran insects for studying the molecular aspects of metamorphosis because of its large size, availability of mutants and genome sequence. Besides, this insect also has been amply studied from a physiological and biochemical perspective. Deep sequencing of small RNAs isolated from different stages of silkworm is a powerful tool not only for measuring the changes in miRNA profile but also for discovering novel miRNAs.
- Publication
BMC genomics, 2010, Vol 11, p52
- ISSN
1471-2164
- Publication type
Journal Article
- DOI
10.1186/1471-2164-11-52