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- Title
Array comparative genomic hybridization analysis of Trichoderma reesei strains with enhanced cellulase production properties.
- Authors
Vitikainen, Marika; Arvas, Mikko; Pakula, Tiina; Oja, Merja; Penttilä, Merja; Saloheimo, Markku
- Abstract
Trichoderma reesei is the main industrial producer of cellulases and hemicellulases that are used to depolymerize biomass in a variety of biotechnical applications. Many of the production strains currently in use have been generated by classical mutagenesis. In this study we characterized genomic alterations in high-producing mutants of T. reesei by high-resolution array comparative genomic hybridization (aCGH). Our aim was to obtain genome-wide information which could be utilized for better understanding of the mechanisms underlying efficient cellulase production, and would enable targeted genetic engineering for improved production of proteins in general.
- Publication
BMC genomics, 2010, Vol 11, p441
- ISSN
1471-2164
- Publication type
Journal Article
- DOI
10.1186/1471-2164-11-441