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- Title
High-content siRNA screening of the kinome identifies kinases involved in Alzheimer's disease-related tau hyperphosphorylation.
- Authors
Azorsa, David O; Robeson, RiLee H; Frost, Danielle; Meec hoovet, Bessie; Brautigam, Gillian R; Dickey, Chad; Beaudry, Christian; Basu, Gargi D; Holz, David R; Hernandez, Joseph A; Bisanz, Kristen M; Gwinn, Leslie; Grover, Andrew; Rogers, Joseph; Reiman, Eric M; Hutton, Michael; Stephan, Dietrich A; Mousses, Spyro; Dunckley, Travis
- Abstract
Neurofibrillary tangles (NFT), a cardinal neuropathological feature of Alzheimer's disease (AD) that is highly correlated with synaptic loss and dementia severity, appear to be partly attributable to increased phosphorylation of the microtubule stabilizing protein tau at certain AD-related residues. Identifying the kinases involved in the pathologic phosphorylation of tau may provide targets at which to aim new AD-modifying treatments.
- Publication
BMC genomics, 2010, Vol 11, p25
- ISSN
1471-2164
- Publication type
Journal Article
- DOI
10.1186/1471-2164-11-25