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- Title
Effort required to finish shotgun-generated genome sequences differs significantly among vertebrates.
- Authors
Blakesley, Robert W; Hansen, Nancy F; Gupta, Jyoti; McDowell, Jennifer C; Maskeri, Baishali; Barnabas, Beatrice B; Brooks, Shelise Y; Coleman, Holly; Haghighi, Payam; Ho, Shi-Ling; Schandler, Karen; Stantripop, Sirintorn; Vogt, Jennifer L; Thomas, Pamela J; Bouffard, Gerard G; Green, Eric D; NISC Comparative Sequencing Program
- Abstract
The approaches for shotgun-based sequencing of vertebrate genomes are now well-established, and have resulted in the generation of numerous draft whole-genome sequence assemblies. In contrast, the process of refining those assemblies to improve contiguity and increase accuracy (known as 'sequence finishing') remains tedious, labor-intensive, and expensive. As a result, the vast majority of vertebrate genome sequences generated to date remain at a draft stage.
- Publication
BMC genomics, 2010, Vol 11, p21
- ISSN
1471-2164
- Publication type
Journal Article
- DOI
10.1186/1471-2164-11-21