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- Title
Gene expression profiling in C57BL/6J and A/J mouse inbred strains reveals gene networks specific for brain regions independent of genetic background.
- Authors
de Jong, Simone; Fuller, Tova F; Janson, Esther; Strengman, Eric; Horvath, Steve; Kas, Martien J H; Ophoff, Roel A
- Abstract
We performed gene expression profiling of the amygdala and hippocampus taken from inbred mouse strains C57BL/6J and A/J. The selected brain areas are implicated in neurobehavioral traits while these mouse strains are known to differ widely in behavior. Consequently, we hypothesized that comparing gene expression profiles for specific brain regions in these strains might provide insight into the molecular mechanisms of human neuropsychiatric traits. We performed a whole-genome gene expression experiment and applied a systems biology approach using weighted gene co-expression network analysis.
- Publication
BMC genomics, 2010, Vol 11, p20
- ISSN
1471-2164
- Publication type
Journal Article
- DOI
10.1186/1471-2164-11-20