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- Title
Unified translation repression mechanism for microRNAs and upstream AUGs.
- Authors
Ajay, Subramanian S; Athey, Brian D; Lee, Inhan
- Abstract
MicroRNAs (miRNAs) are endogenous small RNAs that modulate gene expression at the post-transcriptional level by binding complementary sites in the 3'-UTR. In a recent genome-wide study reporting a new miRNA target class (miBridge), we identified and validated interactions between 5'-UTRs and miRNAs. Separately, upstream AUGs (uAUGs) in 5'-UTRs are known to regulate genes translationally without affecting mRNA levels, one of the mechanisms for miRNA-mediated repression.
- Publication
BMC genomics, 2010, Vol 11, p155
- ISSN
1471-2164
- Publication type
Journal Article
- DOI
10.1186/1471-2164-11-155