We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Digital gene expression analysis of two life cycle stages of the human-infective parasite, Trypanosoma brucei gambiense reveals differentially expressed clusters of co-regulated genes.
- Authors
Veitch, Nicola J; Johnson, Paul C D; Trivedi, Urmi; Terry, Sandra; Wildridge, David; MacLeod, Annette
- Abstract
The evolutionarily ancient parasite, Trypanosoma brucei, is unusual in that the majority of its genes are regulated post-transcriptionally, leading to the suggestion that transcript abundance of most genes does not vary significantly between different life cycle stages despite the fact that the parasite undergoes substantial cellular remodelling and metabolic changes throughout its complex life cycle. To investigate this in the clinically relevant sub-species, Trypanosoma brucei gambiense, which is the causative agent of the fatal human disease African sleeping sickness, we have compared the transcriptome of two different life cycle stages, the potentially human-infective bloodstream forms with the non-human-infective procyclic stage using digital gene expression (DGE) analysis.
- Publication
BMC genomics, 2010, Vol 11, p124
- ISSN
1471-2164
- Publication type
Journal Article
- DOI
10.1186/1471-2164-11-124