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- Title
Steps toward broad-spectrum therapeutics: discovering virulence-associated genes present in diverse human pathogens.
- Authors
Stubben, Chris J; Duffield, Melanie L; Cooper, Ian A; Ford, Donna C; Gans, Jason D; Karlyshev, Andrey V; Lingard, Bryan; Oyston, Petra C F; de Rochefort, Anna; Song, Jian; Wren, Brendan W; Titball, Rick W; Wolinsky, Murray
- Abstract
New and improved antimicrobial countermeasures are urgently needed to counteract increased resistance to existing antimicrobial treatments and to combat currently untreatable or new emerging infectious diseases. We demonstrate that computational comparative genomics, together with experimental screening, can identify potential generic (i.e., conserved across multiple pathogen species) and novel virulence-associated genes that may serve as targets for broad-spectrum countermeasures.
- Publication
BMC genomics, 2009, Vol 10, p501
- ISSN
1471-2164
- Publication type
Journal Article
- DOI
10.1186/1471-2164-10-501