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- Title
Assessing the genomic evidence for conserved transcribed pseudogenes under selection.
- Authors
Khachane, Amit N; Harrison, Paul M
- Abstract
Transcribed pseudogenes are copies of protein-coding genes that have accumulated indicators of coding-sequence decay (such as frameshifts and premature stop codons), but nonetheless remain transcribed. Recent experimental evidence indicates that transcribed pseudogenes may regulate the expression of homologous genes, through antisense interference, or generation of small interfering RNAs (siRNAs). Here, we assessed the genomic evidence for such transcribed pseudogenes of potential functional importance, in the human genome. The most obvious indicators of such functional importance are significant evidence of conservation and selection pressure.
- Publication
BMC genomics, 2009, Vol 10, p435
- ISSN
1471-2164
- Publication type
Journal Article
- DOI
10.1186/1471-2164-10-435