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- Title
The degree of microbiome complexity influences the epithelial response to infection.
- Authors
Mans, Jeffrey J; von Lackum, Kate; Dorsey, Cassandra; Willis, Shaun; Wallet, Shannon M; Baker, Henry V; Lamont, Richard J; Handfield, Martin
- Abstract
The human microflora is known to be extremely complex, yet most pathogenesis research is conducted in mono-species models of infection. Consequently, it remains unclear whether the level of complexity of a host's indigenous flora can affect the virulence potential of pathogenic species. Furthermore, it remains unclear whether the colonization by commensal species affects a host cell's response to pathogenic species beyond the direct physical saturation of surface receptors, the sequestration of nutrients, the modulation of the physico-chemical environment in the oral cavity, or the production of bacteriocins. Using oral epithelial cells as a model, we hypothesized that the virulence of pathogenic species may vary depending on the complexity of the flora that interacts with host cells.
- Publication
BMC genomics, 2009, Vol 10, p380
- ISSN
1471-2164
- Publication type
Journal Article
- DOI
10.1186/1471-2164-10-380