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- Title
Correlations between RNA and protein expression profiles in 23 human cell lines.
- Authors
Gry, Marcus; Rimini, Rebecca; Strömberg, Sara; Asplund, Anna; Pontén, Fredrik; Uhlén, Mathias; Nilsson, Peter
- Abstract
The Central Dogma of biology holds, in famously simplified terms, that DNA makes RNA makes proteins, but there is considerable uncertainty regarding the general, genome-wide correlation between levels of RNA and corresponding proteins. Therefore, to assess degrees of this correlation we compared the RNA profiles (determined using both cDNA- and oligo-based microarrays) and protein profiles (determined immunohistochemically in tissue microarrays) of 1066 gene products in 23 human cell lines.
- Publication
BMC genomics, 2009, Vol 10, p365
- ISSN
1471-2164
- Publication type
Journal Article
- DOI
10.1186/1471-2164-10-365