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- Title
Molecular signature of cell cycle exit induced in human T lymphoblasts by IL-2 withdrawal.
- Authors
Chechlinska, Magdalena; Siwicki, Jan Konrad; Gos, Monika; Oczko-Wojciechowska, Malgorzata; Jarzab, Michal; Pfeifer, Aleksandra; Jarzab, Barbara; Steffen, Jan
- Abstract
The molecular mechanisms of cell cycle exit are poorly understood. Studies on lymphocytes at cell cycle exit after growth factor deprivation have predominantly focused on the initiation of apoptosis. We aimed to study gene expression profile of primary and immortalised IL-2-dependent human T cells forced to exit the cell cycle by growth factor withdrawal, before apoptosis could be evidenced.
- Publication
BMC genomics, 2009, Vol 10, p261
- ISSN
1471-2164
- Publication type
Journal Article
- DOI
10.1186/1471-2164-10-261