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- Title
In silico miRNA prediction in metazoan genomes: balancing between sensitivity and specificity.
- Authors
van der Burgt, Ate; Fiers, Mark W J E; Nap, Jan-Peter; van Ham, Roeland C H J
- Abstract
MicroRNAs (miRNAs), short approximately 21-nucleotide RNA molecules, play an important role in post-transcriptional regulation of gene expression. The number of known miRNA hairpins registered in the miRBase database is rapidly increasing, but recent reports suggest that many miRNAs with restricted temporal or tissue-specific expression remain undiscovered. Various strategies for in silico miRNA identification have been proposed to facilitate miRNA discovery. Notably support vector machine (SVM) methods have recently gained popularity. However, a drawback of these methods is that they do not provide insight into the biological properties of miRNA sequences.
- Publication
BMC genomics, 2009, Vol 10, p204
- ISSN
1471-2164
- Publication type
Journal Article
- DOI
10.1186/1471-2164-10-204