We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Dynamic sensitivity analysis of biological systems.
- Authors
Wu, Wu Hsiung; Wang, Feng Sheng; Chang, Maw Shang
- Abstract
A mathematical model to understand, predict, control, or even design a real biological system is a central theme in systems biology. A dynamic biological system is always modeled as a nonlinear ordinary differential equation (ODE) system. How to simulate the dynamic behavior and dynamic parameter sensitivities of systems described by ODEs efficiently and accurately is a critical job. In many practical applications, e.g., the fed-batch fermentation systems, the system admissible input (corresponding to independent variables of the system) can be time-dependent. The main difficulty for investigating the dynamic log gains of these systems is the infinite dimension due to the time-dependent input. The classical dynamic sensitivity analysis does not take into account this case for the dynamic log gains.
- Publication
BMC bioinformatics, 2008, Vol 9 Suppl 12, pS17
- ISSN
1471-2105
- Publication type
Journal Article
- DOI
10.1186/1471-2105-9-S12-S17