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- Title
Defining functional distances over gene ontology.
- Authors
del Pozo, Angela; Pazos, Florencio; Valencia, Alfonso
- Abstract
A fundamental problem when trying to define the functional relationships between proteins is the difficulty in quantifying functional similarities, even when well-structured ontologies exist regarding the activity of proteins (i.e. 'gene ontology' -GO-). However, functional metrics can overcome the problems in the comparing and evaluating functional assignments and predictions. As a reference of proximity, previous approaches to compare GO terms considered linkage in terms of ontology weighted by a probability distribution that balances the non-uniform 'richness' of different parts of the Direct Acyclic Graph. Here, we have followed a different approach to quantify functional similarities between GO terms.
- Publication
BMC bioinformatics, 2008, Vol 9, p50
- ISSN
1471-2105
- Publication type
Journal Article
- DOI
10.1186/1471-2105-9-50