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- Title
A new protein linear motif benchmark for multiple sequence alignment software.
- Authors
Perrodou, Emmanuel; Chica, Claudia; Poch, Olivier; Gibson, Toby J; Thompson, Julie D
- Abstract
Linear motifs (LMs) are abundant short regulatory sites used for modulating the functions of many eukaryotic proteins. They play important roles in post-translational modification, cell compartment targeting, docking sites for regulatory complex assembly and protein processing and cleavage. Methods for LM detection are now being developed that are strongly dependent on scores for motif conservation in homologous proteins. However, most LMs are found in natively disordered polypeptide segments that evolve rapidly, unhindered by structural constraints on the sequence. These regions of modular proteins are difficult to align using classical multiple sequence alignment programs that are specifically optimised to align the globular domains. As a consequence, poor motif alignment quality is hindering efforts to detect new LMs.
- Publication
BMC bioinformatics, 2008, Vol 9, p213
- ISSN
1471-2105
- Publication type
Journal Article
- DOI
10.1186/1471-2105-9-213