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- Title
Conserved co-expression for candidate disease gene prioritization.
- Authors
Oti, Martin; van Reeuwijk, Jeroen; Huynen, Martijn A; Brunner, Han G
- Abstract
Genes that are co-expressed tend to be involved in the same biological process. However, co-expression is not a very reliable predictor of functional links between genes. The evolutionary conservation of co-expression between species can be used to predict protein function more reliably than co-expression in a single species. Here we examine whether co-expression across multiple species is also a better prioritizer of disease genes than is co-expression between human genes alone.
- Publication
BMC bioinformatics, 2008, Vol 9, p208
- ISSN
1471-2105
- Publication type
Journal Article
- DOI
10.1186/1471-2105-9-208