We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Improving the prediction of mRNA extremities in the parasitic protozoan Leishmania.
- Authors
Smith, Martin; Blanchette, Mathieu; Papadopoulou, Barbara
- Abstract
Leishmania and other members of the Trypanosomatidae family diverged early on in eukaryotic evolution and consequently display unique cellular properties. Their apparent lack of transcriptional regulation is compensated by complex post-transcriptional control mechanisms, including the processing of polycistronic transcripts by means of coupled trans-splicing and polyadenylation. Trans-splicing signals are often U-rich polypyrimidine (poly(Y)) tracts, which precede AG splice acceptor sites. However, as opposed to higher eukaryotes there is no consensus polyadenylation signal in trypanosomatid mRNAs.
- Publication
BMC bioinformatics, 2008, Vol 9, p158
- ISSN
1471-2105
- Publication type
Journal Article
- DOI
10.1186/1471-2105-9-158