We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Polymorphism Interaction Analysis (PIA): a method for investigating complex gene-gene interactions.
- Authors
Mechanic, Leah E; Luke, Brian T; Goodman, Julie E; Chanock, Stephen J; Harris, Curtis C
- Abstract
The risk of common diseases is likely determined by the complex interplay between environmental and genetic factors, including single nucleotide polymorphisms (SNPs). Traditional methods of data analysis are poorly suited for detecting complex interactions due to sparseness of data in high dimensions, which often occurs when data are available for a large number of SNPs for a relatively small number of samples. Validation of associations observed using multiple methods should be implemented to minimize likelihood of false-positive associations. Moreover, high-throughput genotyping methods allow investigators to genotype thousands of SNPs at one time. Investigating associations for each individual SNP or interactions between SNPs using traditional approaches is inefficient and prone to false positives.
- Publication
BMC bioinformatics, 2008, Vol 9, p146
- ISSN
1471-2105
- Publication type
Journal Article
- DOI
10.1186/1471-2105-9-146