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Title
Evolutionary Pareto-optimization of stably folding peptides.
Authors
Gronwald, Wolfram; Hohm, Tim; Hoffmann, Daniel
Abstract
As a rule, peptides are more flexible and unstructured than proteins with their substantial stabilizing hydrophobic cores. Nevertheless, a few stably folding peptides have been discovered. This raises the question whether there may be more such peptides that are unknown as yet. These molecules could be helpful in basic research and medicine.